Rose Wylie was born in Kent, United Kingdom, in 1934. She studied at Folkestone and Dover School of Art in Kent, United Kingdom, and Royal College of Art in London, United Kingdom. 

Wylie's recent solo and group exhibitions include "Rose Wylie: When Found becomes Given" at David Zwirner in London, United Kingdom (2025); "Rose Wylie. Flick and Float" at Zentrum Paul Klee in Bern, Switzerland (2025); "Love Poems: Singing In Unison, Part 11" curated by Chris Martin at Anton Kern Gallery in New York, New York (2025); "Loewe Salon" at Palazzo Citterio in Milan, Italy (2025); "Summer Exhibition 2025" at Royal Academy of Arts in London, United Kingdom (2025); "Football City, Art United" curated by Juan Mata, Hans Ulrich Obrist, and Josh Willdigg at Aviva Studios in Manchester, United Kingdom (2025); "Rose Wylie: Stack and Dangle" at Jari Lager Gallery in Cologne, Germany (2024); "Forever Young" at Veta Gallery in Madrid, Spain (2024); "GLASSTRESS 8 1/2" at Fondazione Berengo Art Space in Venice, Italy (2024); "Drawing Biennial 2024" at The Drawing Room in London, United Kingdom (2024); "Made in Cologne" at Peter Freeman, Inc. in New York, New York (2024); "David Zwirner: 30 Years" at David Zwirner in Los Angeles, California (2024); "Summer Exhibition 2024" at Royal Academy of Arts in London, United Kingdom (2024); "Rose Wylie: CLOSE, not too close" at David Zwirner in Los Angeles, California (2023); "Rose Wylie: Car and girls, David Zwirner in London, United Kingdom (2022); and "Rose Wylie: picky people notice...," at Stedelijk Museum voor Actuele Kunst (S.M.A.K.) in Ghent, Belgium (2022).

Wylie's work is held in public collections including the Arts Council of England; the London British Council; the David Roberts Foundation in London, United Kingdom; the Government Art Collection in the United Kingdom; the Hammer Museum in Los Angeles, California; High Museum of Art in Atlanta, Georgia; the Jerwood Foundation in London, United Kingdom; the Monsoon Collection in London, United Kingdom; Museum Ludwig in Cologne, Germany; the National Museum of Women in the Arts in Washington, D.C.; the New Hall Collection in Cambridge, United Kingdom; Norwich Gallery in Norwich, United Kingdom; Pallant House Gallery in Chichester, United Kingdom; Royal College of Art in London, United Kingdom; Space K in Seoul, South Korea; Städtische Galerie in Wolfsburg, Germany; the Student Collection at University College in Oxford, United Kingdom; Tate Britain in London, United Kingdom; Walker Art Gallery in Liverpool, United Kingdom; York City Art Gallery in York, United Kingdom; and the Zabludowicz Collection in London, United Kingdom.

Rose Wylie lives and works in Kent, United Kingdom.